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The de-S-nitrosylation of G6PD could be a compensatory response to decreased NO and increased ROS generation during EC senescence

FIGURE 9 Discussion Hyperglycemia-induced chronic inflammation and metabolic dysregulation play a crucial role in the micro- and macro-vascular complications of diabetes and are associated with long-term dysfunction of various organs, especially the liver and kidneys ( Despite the benefits of pharmacological therapies, prophylactic approaches such as physical exercise, besides caloric restriction are considered the cornerstone in the management of type 2 diabetes ( Our previous study in GK rat pancreas demonstrated exercise-induced beneficial effects by improving energy metabolism, antioxidant responses and mitochondrial functions, and metabolic adaptation ( via the AMPK/SIRT-1/PPAR- signaling pathways

Acetyl-11-Keto-Beta-Boswellic acid activates the Nrf2/HO-1 signaling pathway in Schwann cells to reduce oxidative stress and promote sciatic nerve injury repair

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Photoprotection Research Preclinical studies have explored the potential of Melanotan 2 to enhance the skins natural defenses against ultraviolet (UV) radiation, making it a valuable tool for investigating photoprotective mechanisms and anti-aging strategies