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The results are striking: across benchmarks involving unseen cell types, unseen drugs, and even different experimental platforms, CRISP outperforms existing methods (e.g., +24.5% correlation gain on held-out cell types)

The authors hypothesized that Vit B12 has an important role in the metabolism of homocysteine, increased levels of which are responsible for the loss of pigment due to deficient methionine synthesis

Low levels of blood vitamin C and the resulting accumulation of ROS are thought to be detrimentalespecially to aging populations.

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Accumulation of selective ceramides species might target and disrupt mitochondria function leading to neurodegeneration (Lima et al., 2023)