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The HPA axis also integrates into this network: gut microbes can affect cortisol dynamics by influencing the hosts metabolism of tryptophan into metabolites like kynurenine that impact HPA feedback loops [46, 47]

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l-Theanine Prevents Colonic Damage Via NF-B/MAPK Signaling Pathways Induced by a High-Fat Diet in Rats[J] 68 (8), e2300797 (Molecular nutrition & food research, 2024)

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In this trial, the patients studied at 13 years post diagnosis were likely to have lost the majority of nigral and striatal dopaminergic function 56