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Some patients report feeling unsteady when walking, particularly in the dark, because proprioception (the sense of where your body is in space) is impaired

NICE stands for National Institute of Health and Care Excellence

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Dysregulated iron homeostasis amplifies ferroptotic susceptibility through Fenton chemistry-driven lipid peroxidation and polyamine synthesis via the ODC1-MYC axis, a metabolic and oxidative cascade prominently observed in the inflamed synovium of rheumatoid arthritis ( Inducing ferroptosis in specific cell populations using agents like Imidazole ketone erastin (IKE) can suppress synovial fibroblast proliferation and inflammation (104)

Surprisingly, overexpression of either spliced XBP1 (XBP1s) or unspliced XBP1 (XBP1u) failed to re-sensitize IRE1-null MDA-MB-231 cells to ferroptosis induction (Fig