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ASK1, also known as MAP3K5, activates the downstream p38-JNK1/2 signalling pathway, thereby promoting inhibition of lipid and glucose metabolism 34,35,36 and driving a strong inflammatory response 37

CrossRef A comprehensive analysis of the impact of smoking on adverse clinical outcomes of steatotic liver diseases Keungmo Yang, Jaejun Lee, Ji Won Han, Hyun Yang, Seung Yun Chae, Beom Sun Chung, Tom Ryu Therapeutic Advances in Gastroenterology .2025;[Epub] CrossRef Current burden of steatotic liver disease and fibrosis among adults in the United States, 20172023 Donghee Kim, Pojsakorn Danpanichkul, Karn Wijarnpreecha, George Cholankeril, Rohit Loomba, Aijaz Ahmed Clinical and Molecular Hepatology .2025

Hu Z, Mi Y, Qian H, Guo N, Yan A, Zhang Y, et al

This was the first report describing an African mouse species with remarkable skin (and other tissue) regenerative capacity, which has led to comparative studies to unravel the mechanisms underpinning its exceptional healing

ZnT4-deficient mice exhibit the classic lethal milk phenotype, in which mammary zinc secretion fails and offspring perish without supplementation 170,171,172