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Xia et al., 2020

Tesofensine is an oral small-molecule triple monoamine reuptake inhibitor not a peptide developed for weight loss and studied in Phase 2 trials as a once-daily 0.5 mg capsule

Research overview About BPC-157 BPC-157 is a synthetic pentadecapeptide a fifteen-amino-acid chain whose sequence corresponds to a partial fragment of a protein originally identified in gastric juice and described in the scientific literature

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The pharmacokinetic properties of a peptide are optimized using chemical modifications such as changing l-amino acids with d-amino acids, cyclization, conjugation (e.g., acylation, pegylation, glycosylation), amide bond protection (e.g., N-methyl groups), and incorporation of altered or unnatural amino acids (e.g., tert-butyl group on serin)