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Despite preliminary findings suggesting polarity-dependent analgesic effects, the overall evidence remains limited, highlighting the need for more rigorous and standardized investigations

-hydroxybutyrate, the most abundant ketone body, is mainly synthesized in the liver from circulating fats during times of starvation, extended exercise, or when carbohydrate intake is limited [41]

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2.6 PICRUSt2 functional prediction analysis Phylogenetic studies of the cohort were performed by reconstructing the unobserved state 2 (PICRUST2) to predict the functional potential of the bacterial community

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