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It can cause injury to the vein and can affect blood flow, leading to DVT

doi: 10.1021/jf030022f

Numbing creams are usually applied to minimize pain during the procedure

Some HMs indirectly impose oxidative stress through a variety of mechanisms, including the depletion of glutathione, the binding of sulfhydryl groups of proteins (Jaishankar et al., 2014), the inhibition of antioxidative enzymes, or the induction of ROS-producing enzymes such as NADPH oxidases (Singh et al., 2015)