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Four molecule families have peer-reviewed clinical evidence supporting their use in microinfusion-style delivery: copper tripeptide GHK-Cu (collagen synthesis, gene-expression modulation), recombinant epidermal growth factor or sh-Oligopeptide-1 (keratinocyte proliferation, dermal restructuring), polydeoxyribonucleotide PDRN (adenosine A2A receptor activation, fibroblast stimulation, anti-melanogenesis), and a multi-molecular-weight hyaluronic acid system (50 kDa to 2000 kDa fractions, each with different penetration depth and biological role)

Some women report increased nausea during certain phases

When stored correctly, a reconstituted peptide in Bacteriostatic Water is typically stable for several weeks (check specific research guidelines, but 3-4 weeks is a common timeframe)

Jul 23 2021;61(1):140-153