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Nevertheless, a key question to be addressed is whether Mn toxicity results primarily from the direct effects of excess Mn or is due to a secondary consequence of altered systemic metal homeostasis

Acknowledgments The authors would like to thank Wrwag Pharma for making the present work possible

doi: 10.2164/jandrol.110.012583 118 ZhouNJiangCChenQYangHWangXZouPet al

and (ii) proliferative astrogliosis, which is anisomorphic with loss of domain, substantial structural reorganisation and can either be diffuse or can result in the formation of new compact limitans borders around overt fibrotic tissue lesions (Fig