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2018 Nature Communications paper (NR reduced blood pressure and arterial stiffness in healthy middle-aged adults), and numerous pharmacokinetic studies Animal lifespan data: While NAD+ precursors have shown healthspan improvements in mice (improved physical activity, insulin sensitivity, mitochondrial function), clear lifespan extension data is more limited and inconsistent DNA repair: Studies demonstrated restored PARP-dependent DNA repair in aged mice and radiation-exposed human cells following NAD+ repletion Stem cell rejuvenation: NMN restored aged muscle stem cell function and improved hematopoietic stem cell parameters in mice Epidemiological data: NAD+ levels correlate with biological age across multiple cohort studies, establishing translational relevance Key limitations: Despite abundant evidence for NAD+ restoration, the downstream clinical benefits in humans are still being established

Its been 19 days since my second dose (Moderna), some days Im ok other days Im having episodes of dizziness, sinus pressure, anxiety, and slightly high blood pressure

References Lopaschuk GD, Karwi QG, Tian R, Wende AR, Abel ED

Matrix stiffness triggers lipid metabolic cross-talk between tumor and stromal cells to mediate bevacizumab resistance in colorectal cancer liver metastases

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