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Importantly, some of these structural abnormalities persist despite levothyroxine replacement, reflecting the inadequacy of systemic therapy in restoring intracerebral hormone balance (79, 80)

Moreover, c-Myc alterations contribute to acquired resistance to c-Met inhibitors in different MET-overexpressed cancers [152]

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While this drug will not be helpful as a treatment for FTD, the fact that full regulatory approval has been granted to a treatment that slows the progression of a neurodegenerative disease offers tremendous hope for future breakthroughs in FTD, Dr