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Third, these compounds may impact the host cell, including its cellular metabolism

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4F, Supplementary Fig

This process enables the endometrium to acquire a receptive phenotype, promoting embryo implantation and pregnancy maintenance by providing a nutritive and immunoprivileged environment ( Figure 1 Concurrently, during decidualization, the differentiation of stromal cells is accompanied by significant metabolic changes, with glucose serving as a primary energy source ( Aberrant glucose metabolism, characterized by dysregulated glucose uptake or glycolysis in human endometrial stromal cells (hESCs), contributes to decidualization deficiencies and subsequent embryo implantation failure ( Figure 1 )