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People with dietary restrictions, such as vegans and vegetarians, who may not get sufficient B12 from their diet, or those with absorption issues, like those with pernicious anemia or gastrointestinal disorders, also often qualify

By contrast, in studies including patients with SCA, BCL11A levels and SNPs were not found to be correlated with HbF induction after HU treatment [58], [59], [60], suggesting an important role for BCL11A in controlling baseline HbF levels, but with other factors required for HU to increase HbF levels

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B12 injections can also be a bit painful, especially for people without much body fat

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