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All candidates had to be free of underlying medical conditions, as verified through medical history, physical examination, ECG, chest X-ray (posteroanterior view), and laboratory assessments performed within 7 days before the study began

Enzymatic Antioxidant Upregulation Studies in aged rats demonstrated epithalamin and epitalon increased activities of key antioxidant enzymes in brain tissue [7] : This differs from melatonins direct radical scavenging