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A patient who is subclinically deficient has the same impaired wound healing, the same elevated clotting risk, and the same anaemia vulnerability as a patient with obvious symptoms

Cell Death & Differentiation 2006;13, 12561259, doi: Kruiswijk, F., Labuschagne, C

[2] The MHRA Drug Safety Update (August 2022) advises healthcare professionals to consider testing vitamin B12 levels in patients taking metformin who develop symptoms of neuropathy or anaemia, and to consider periodic monitoring in those at risk of deficiency

The mass change as a function of the immersion time was calculated as m(t) = m 2 (t) m 1

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