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When a patient on a stable transdermal estradiol regimen cannot fill her prescription because patches are on backorder, the prescriber faces a clinical decision: switch to an oral formulation (with a different risk profile), switch to a different delivery system the patient hasnt used before, or consider a compounded transdermal estradiol preparation that delivers the same active ingredient through the same route

For dermatology prescribers who send compound orders regularly, routing those orders exclusively to accredited pharmacies is the simplest way to control for quality variability

On average, each session ranges from $100 to $300

Additionally, there is a risk of peptide-related impurities and API characterization as the drug is not regulated by the FDA

The peptide research community continues to explore AOD 9604 for specific applications, and the compound remains popular in certain protocols