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Narayana JK, Aliberti S, Mac Aogin M, Jaggi TK, Ali NABM, Ivan FX, et al

Nuclear Depletion and Cytoplasmic Accumulation of TDP-43 One of the prominent features of ALS and FTLD-TDP, is the loss of functional TDP-43 in the nucleus and its increased deposition into cytoplasmic inclusion bodies in the brain and spinal cord neurons (Arai et al., 2006