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Int J Radiat Oncol 84(3):S842, 2012

In summary, XSJ effectively alleviates liver injury induced by a CDAHFD in mice

Thus, modulating the Fc:FcRn interaction to prolong plasma half-life and attain a favorable biodistribution is a clinical success, and several clinical-stage candidate therapeutics harbor either the YTE or LS amino acid substitutions, or a more recently reported triple Fc mutant variant (Q311R/M428E/N434W