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The effect of TZDs on insulin sensitivity is mediated by the activation of PPAR, a nuclear receptor that regulates the transcriptions of several genes involved in glucose and lipid metabolism and energy balance and increases fat oxidation, adipocyte proliferation, lipogenesis, fat redistribution, and reduces plasma free fatty acid and pro-inflammatory cytokine levels [159]

In NSCLC, p53 inhibits tumor growth by promoting pyroptosis (101)

L-carnitine is essential for transporting long-chain fatty acids across mitochondrial membranes

Consequently, they are more susceptible to the accumulation of free radicals