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Dose may be titrated gradually and given up to twice a week depending on the condition and desired outcomes

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Active IRE1 processes the unspliced X-box binding protein 1 ( uXBP1 ) mRNA, producing the active transcription factor spliced XBP1 (sXBP1), which regulates genes involved in protein folding and ER-associated degradation [9]

10.1186/s40199-014-0072-7 188 SiddiquiS

Excitotoxicity causes massive calcium influx, activating calcium-dependent proteases and NOS, which rapidly trigger MMP-9 activation, leading to the swift degradation of tight junctions and the basement membrane (166)