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Assuming an increased ROS-level and a decreased level of glutathione, especially the reduced form, as an important antioxidant in Wobbler motor neurons, it can be concluded that NAC, as a precursor of glutathione, can replenish the GSH content and thus reduce oxidative stress in Wobbler motor neurons resulting in less oxidative DNA damage

c,dJIMMY GUTMAN, MD aWashington Dermatology Center, North Bethesda, Maryland

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