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Description

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

H.DohnerH.PocockC.MontesinosP.AfanasyevB.DombretH.et al (2020)

This indicates the complexity of the research, necessitating more comprehensive and in-depth investigations

Despite that low penetrance, partial deficiency of CCT in B cells resulted in decreased peritoneal and splenic B cell numbers, inducing a compromised proliferation, especially in the periphery, decreasing serum IgG concentration, and increasing the incidence of IgM-secreting cells (107)