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Clin Chim Acta 348(12):6368 Seetharaman AT, Owens CE, Gangaraju R (2024) Cysteinyl leukotriene receptor antagonism by montelukast to treat visual deficits

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A study evaluating the hepatotoxicity of columbin (CLB) demonstrated that CLB induces DNA damage both in vitro and in vivo, which is associated with the upregulation of PARP-1 (27)

Although these changes are consistent with ferroptosis inhibition, the studies did not employ ferroptosis-specific pharmacological inhibitors (eg, Fer-1, Lip-1) or genetic tools (eg, GPX4 knockdown) to establish causality

W.RotenbergA.WangJ.et al (2021)