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Impaired mitophagy and fragmented mitochondrial morphology are emerging as novel contributors to neuronal vulnerability in AD (Cao et al., 2019)

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Ligand binding locks the inactive conformation and ensures very low spontaneous thermal activation of the receptor, in the dark state what is referred to as dark noise 4

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Stay upright after eating : Waiting 2-3 hours before lying down allows digestion to stabilize, lowering acid reflux risk, especially after late-night snacks