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Kranz RG, Richard-Fogal C, Taylor JS, Frawley ER (2009) Cytochrome c biogenesis: mechanisms for covalent modifications and trafficking of heme and for heme-iron redox control

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Animals suffering from EPI can become deficient in multiple nutrients including B12, because they can not absorb it from the food they eat

We note, however, that the reported concentration of free heme in the mitochondrial matrix is in the low nanomolar range 74

VDAC-dependent permeabilization of the outer mitochondrial membrane by superoxide induces rapid and massive cytochrome c release [J]