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Journal of Biological Chemistry , 280(19), 19726-19736

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However, the active form of vitamin B12 (methylcobalamin) is more bioavailable than the synthetic form (cyanocobalamin).[15] The synthetic form of B12 should be used with caution in patients with renal impairment due to possible accumulation of aluminum, used in the preparation of synthetic vitamin B12.[15] Hydroxocobalamin is another alternative offered as an injection with a longer half-life and is safe for patients with renal impairment

Consistent with these studies, we have omitted use of E2 and/or EE2 in our experiments to focus specifically on BPA-induced effects