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SP can target the macrophages to accelerate the protein degradation of Kelch-like ECH-associated protein 1 (KEAP1) via microtubule-associated protein 1 light chain 3 (LC3)-mediated autophagy and ubiquitin-mediated proteasome degradation

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In addition, activated Akt can relinquish the inhibition of mammalian target of rapamycin (mTOR) signaling pathways and promote proteins synthesis (Fig