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The direct comparison of the transcriptomes of the two NaNO 2 treated cultures revealed that glucose utilization genes, lipid biosynthesis genes, siderophore cluster genes, Cazyme genes, glutathione S-transferase (GST) genes, and ammonia assimilation genes showed higher transcriptional activity, while ribosome biogenesis genes showed lower transcriptional activity in the 135 mM treated cultures than in the 90 mM treated group (Additional files 2 and 6)

found that ASCT2 ligands chloroalanine, aminooxetane-3-carboxylate (AOC), and -FBP also inhibit ASCT2-mediated glutamine uptake in human melanoma cells [104]

After the initial infection of the skin (stage 1), the spirochete often disseminates to many sites (stage 2), particularly to other skin sites, the nervous system, heart or joints, where it might cause persistent infection (stage 3) for years