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performed a metabolism study with bromfenac to scrutinize the formation of reactive intermediates and their linkage to the hepatotoxicity of this compound ( In vitro studies have revealed that bromfenac requires conjugation by UGTs to form a bromfenac glucuronide intermediate that cyclizes to a major metabolite, bromfenac indolinone (BI)

Complex in vitro model: a transformative model in drug development and precision medicine

[25] Malignant cells often exhibit a heightened demand for iron, fueling their transition towards a more invasive mesenchymal state

Here, we provide a comprehensive overview of the complex interplay between Mn metabolism and various diseases, integrating insights gleaned from environmental Mn toxicity, inherited Mn transportopathies, and their molecular mechanisms