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Parkin (i.e., Park2) is an E3 ubiquitin ligase that is believed to play an important role in directing misfolded proteins for degradation via the ubiquitin-protease system 74 and helps regulate mitochondrial dynamics through mitochondrial biogenesis, import of mitochondrial proteins and mitophagy (targeting mitochondria to phagosomes) 75

Zhong S, Bird A, Kopec RE

Spindel ON, Yan C, Berk BC

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Evidence suggests that the management of inflammation should commence when levels of pro-inflammatory factors are significantly elevated or when there is a dysregulation in the inflammatory response