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The interconnectedness of these factors drives the progression of the disease, and although some results have been achieved, in-depth investigations are still needed to clarify the mechanisms and guide treatment

While the methylation cycle gets a lot of press, the metabolism of homocysteine-thiolactone is also really important

Nucleic Acids Res 35:W375383 de Pablo P, Chapple IL, Buckley CD, Dietrich T (2009) Periodontitis in systemic rheumatic diseases

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Glucuronidation is a key Phase II detoxification pathway, responsible for processing non-polar drugs from all therapeutic classes, as well as bilirubin and excess steroid hormones like estrogen