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The volume of studies already carried out using CDNSs shows that these systems are very promising for pharmaceutical and biomedical applications, especially for the delivery and controlled release of drugs

Furthermore, the lactate metabolizing enzyme LDHB promotes H3K18 histone lactoylation, enhances ACSL4 expression, and induces chondrocyte ferroptosis, representing another epigenetic regulatory target for OA (171)

Future opportunities include hybrid nanoplatforms that integrate redox responsiveness with imaging and enhanced safety, as well as the use of patient-specific GSH/GSSG profiles to guide individualized therapy

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There are diverse theories of aging [238] that basically point to few broad physiological processes important for longevity: genetic stability, telomere shortening, stress resistance and metabolic control