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IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling

The output from the David database produced 178 clusters, and the top two clusters with the highest enrichment scores were Annotation Cluster 1 (enrichment score 7.39) and Annotation cluster 2 (enrichment score 5.94) (Table 2)