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In our previous study, a series of 6-dithio-2-deoxyguanosine analogs, including 6-sec-butyl dithio-2-deoxyguanosine (YLS001), 6-p-fluorobenzyl dithio-2-deoxyguanosine (YLS002), 6-tert-butyl dithio-2-deoxyguanosine (YLS003), and 6-isopropyl dithio-2-deoxyguanosine (YLS004, also named thiotert), have been designed and synthesized, and in colon cancer and melanoma cells, we found thiotert significantly dampens TRXR1/TRX1 system activity and telomerase expression more than the other 3 analogs [45]

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