Readers interested in this outcome area may also want to review our guides on peptides for skin research and what GHK-Cu is, a copper peptide studied for many of the same connective-tissue pathways available as GHK-Cu
Do not stop treatment without consulting your doctor
Retatrutide produced an average weight reduction of 24.2% at the 12 mg dose after 48 weeks in its Phase 2 obesity trial, according to Jastreboff and colleagues (NEJM, 2023
Important safety considerations include: Inform your GP about all supplements you are taking Avoid self-treating suspected deficiency without medical assessment, as supplementation can mask underlying pernicious anaemia whilst allowing neurological damage to progress Do not start high-dose folic acid supplements before B12 deficiency is excluded, as this can worsen neurological damage Check for interactions if taking medications such as metformin, chloramphenicol, or proton pump inhibitors Monitor response through appropriate blood tests if treating deficiency Pregnant women, individuals with Leber's disease (a rare hereditary eye condition), and those with cobalt allergy should consult healthcare professionals before supplementing
When a compound average effect is only 2 kilograms over 12 weeks, many individual participants likely saw minimal to no change, while a smaller subset may have responded more strongly, pulling the average up
