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Nat Rev Microbiol 17:247260

Authors contributions Research design (XL, KZ, FW, JC), literature search and evidence synthesis (XL, RD, PJ, XtW, GG, XW, CX, HL), and writing of the manuscript (XL, RD)

*Correspondence: Wei Wei, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

When this score rises, it usually signals a poor prognosis for the cancer

These results confirm that ubiquitylation of IL-1 at K133 is required for efficient proteasomal degradation of TLR-induced IL-1