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doi: 10.3389/fmed.2018.00061

Therefore, the reduction in cortical BDNF delivery would result in diminished activity of the cortex and striatum synaptic activity and resulting in synaptic loss

Several phenolic compounds identified through HPLC-MS, such as syringic acid and 4-hydroxybenzoic acid, have been previously reported in the literature for their potent antioxidant properties, suggesting their potential contribution to the ROS-scavenging effects of FPM [62, 63]

In summary, dysbiosis might contribute to neurodegeneration by disrupting metabolic homeostasis reducing beneficial metabolites (SCFAs, vitamins) and increasing potentially neurotoxic ones (e.g

[5] Toxicity, safety, and potential side effects [edit] General observations [edit] There is limited safety information available on the effects of kava consumption, but in general, moderate consumption appears unlikely to be harmful, while there is evidence of harm from heavy use