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Three weeks of six days per week high intensity resistance training increased oxidative stress in blood as indicated by serum thiobarbituric acid-reacting substances (TBARS), which is an indicator of lipid peroxidation, by 56% while reducing whole blood total glutathione content (GSH) by 31% (an endogenous antioxidant), and total antioxidant capacity (TAC) by 20% [11]

The net effect is an overall transcriptional block, preventing a patients white blood cells from properly developing [2]

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Cells 11(3):383 Li J, Wang Z, Li C, Song Y, Wang Y, Bo H et al (2022) Impact of exercise and aging on mitochondrial homeostasis in skeletal muscle: roles of ROS and epigenetics