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Zerbi (Ospedale S

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PBPK models for both victim and perpetrator compounds can be linked through appropriate interaction mechanisms, such as reversible inhibition (RI) or time-dependent inhibition (TDI), to simulate PK-mediated DDIs [136]

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FAO substrates are derived from the external environment via specific transporters able to mediate fatty acid uptake, such as CD36 (Figure 3)

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