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Historically, LT for ALD has been controversial, partly due to perceptions of ALD being a self-inflicted condition [106]

However, if the adaptive immune response in the acute model is maintained by peripherally administering cytokines such as RANTES (Regulated on Activation, Normal T cell Expressed and Secreted) and eotaxin twice a week, the inflammation is sustained and pSYN accumulates in the SN of the rodents (203)