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C.GengY

Nature Reviews Drug Discovery, 10 , 767777

Caspase-1 activation has been observed in experimental rat models of rhabdomyolysis,34 whereas the use of ferroptosis inhibitors in these rats reduced cell death of proximal tubules.49 Lastly, the accumulation of haemoproteins and their derivatives may induce autophagy as a defence mechanism.46,50,51 Fibrosis Renal fibrosis is another mechanism involved in renal damage caused by haemoproteins

Accordingly, feeding worms with DB - a diet deficient in low molecular weight (LMW) thiols, increases the lifespan of wt animals by 58%, but only marginally affected nuo-6 worms (12% increase, Supplementary Fig