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Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-l-cysteine

Cells (2020) 9(11)

A substantial depletion of cellular ATP contents of astrocytes has severe concequences on astrocytic viability [62, 79, 135] and has been connected with impaired astroglial glutamate uptake [136, 137] and cell swelling induced release of excitatory amino acids [138, 139]

Targeted deletion of adipocytes by apoptosis leads to adipose tissue recruitment of alternatively activated M2 macrophages

To address these gaps, this study utilizes iPSC-derived cerebral organoids (COs) from BD patients and healthy controls to model disease-specific metabolic and inflammatory dysfunction in a more physiologically relevant system