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As a statement made by one of the leaders in vitamin B12 field more than 10 years ago, Carmels idea of cobalamin deficiency should not be diagnosed unless megaloblastic changes are found is still followed by many physicians and health authorities when accepting B12 deficiency diagnosis.1 But as time goes by, evidence and clinical cases showed that B12 deficiency symptoms can be seen even when B12 level in blood is within the reference range, as 200 900 pg/mL in the United States,2 and 135-650 pmol/L in Australia.3 In clinical practice, signs and symptoms of B12 deficiency start when plasma B12 levels are normal, and long historical studies showed that neurological symptoms of deficiency occur in patients without sign of anaemia

Potential in ED: Exosomes derived from stem cells have shown promise in regenerative medicine, promoting tissue repair and quelling inflammation

This study aimed to investigate rhythmicity in NVC and its association with cerebrovascular disease, including stroke and small vessel disease (SVD)

iron supplementation or vitamin replacement as needed) to reduce the risk of a further Hb drop during fasting