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Additionally, as drug release from encapsulated nanoparticles might impact the stability of nanoparticles, more attention needs to be paid to drug release events such as burst release and leakage from nanoparticles

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Graves orbitopathy (GO) is the most prominent and common extrathyroidal manifestation of GD, characterized by the production and accumulation of glycosaminoglycans (especially hyaluronic acid) in the retrobulbar and periorbital tissues causing protrusion of the eyeball and restriction of ocular muscle movement ( Table 1

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There are over 50 TKIs approved by the Food and Drug Administration (FDA), with the ongoing rapid development of new drugs every year

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