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Two groups of nine dogs each were exposed through extracorporeal perfusion for 40 min via a polyvinyl chloride oxygenator containing 12 g ethylene oxide/kg material

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And in the SKYLIGHT 2 trial, which included 500 women, a 57% and 62% reduction in hot flashes was observed at dosages of 30 mg and 45 mg, respectively, after 12 weeks of treatment

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