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Galectin-3 has an AUC of 0.83 with 72.1% sensitivity and 86.1% specificity, while S100A9 has an AUC of 0.77 with 69.8% sensitivity and 58.1% specificity (Table.1)( Figure 4C ) (103)

Both human platelets and mast cells secrete polyP upon activation which indicates that polyP could be an important mediator of their pro-inflammatory and pro-coaguant activities

As a result, there is toxic gain in function of the modified proteins

The body downregulates metabolic rate, adjusts hunger hormones, and becomes more efficient at storing energy

Although Sesn2 was manipulated genetically rather than pharmacologically in that study, both Sesn2 itself and its upstream regulators, mTOR and AMPK, are in principle amenable to small-molecule targeting