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After the inflammatory complex activation of NLRP3, Caspase-1 is markedly activated by the NLRP3 complex to form active Caspase-1

312 Interestingly, existing studies showed that besides the acknowledged inhibitory effects on CS, baricitinib can also dampen ACE2-mediated SARS-CoV-2 endocytosis by inhibiting AP2-associated protein kinase 1 and cyclin G-associated kinase, 313,314 which serves as another mechanism of its action in COVID-19

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doi: 10.1155/2017/8416763 215 Sharifi-RadMAnil KumarNVZuccaPVaroniEMDiniLPanzariniEet al