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Storage for a prolonged period or at an excessive temperature presents the following hazards: * breakage of the capsule by the build up of pressure internally and loss of amyl nitrite before use

To focus on oxidative stress as a main damaging factor in an in vitro model is reasonable, as the diverse upstream causes for PN (hyperglycemia, dyslipidemia, some chemotherapeutics, alcohol abuse) converge into one prominent metabolic disturbance: the production of ROS and, thus, increased oxidative stress

Inside the mitochondrion, MitoQ undergoes redox cycling mediated by complex II, where it is reduced to mitoquinol, known for its potent antioxidant properties (58)