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Inhibition of PDE4 leads to high levels of cAMP, which in turn, activates PKA resulting in phosphorylation of transcription factors, such as cAMP Response Element-binding protein (CREB) and activating transcription factor-1 (ATF-1)

Nature 319 , 774776 (1986)

Short sleep duration and dietary intake: epidemiologic evidence, mechanisms, and health implications

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